Despite large-scale consolidation in the healthcare industry, Bristol-Myers Squibb has remained for the most part on the sidelines, avoiding transformational mega-deals in favour of smaller bolt-ons, primarily in the biopharma sector. Once the world's #1 drug company, it has steadily been pushed down the rankings by mergers or aggressive growth among its competitors. During the 1990s, it sold off several of its non-core lines, followed in 2001 by its central Clairol business (to Procter & Gamble) as well as half of its medical devices portfolio, in order to concentrate on medicines. Several other non-core units were sold or spun off in 2008 and 2009, most significantly the Mead Johnson nutritionals division. Because of its size, BMS is regarded as a potential takeover target. The group entered tentative merger negotiations in 2007 with Sanofi, the developer of its best-selling product, Plavix, which alone accounted for around a third of revenues in 2011. However, no agreement was reached. Plavix lost its patent towards the end of 2012, and several other important patents end in 2014 and 2015, creating a significant challenge for BMS's future performance.
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Adbrands Weekly Update 13th Oct 2016: Shares in pharmaceutical group Bristol-Myers Squibb took another tumble following publication of full details of disappointing recent trial results for its cancer drug Opdivo, previously seen as a major future blockbuster. Initial reports prompted a 20% plunge in BMS stock last month, but the full report is even worse than analysts had anticipated. Opdivo had been conceived as a less gruelling alternative to traditional chemotherapy for certain types of lung cancer. However the full trial results suggest that it is in fact also less effective, not just than chemotherapy but also than rival drug Keytruda, from Merck. The latter also reported new trial data this week, but this showed better than expected results. The sharp contrast between the two announcements caused BMS shares to fall by another 10% to a two-year low.
Adbrands Weekly Update 11th Aug 2016: Shares in drug developer Bristol-Myers Squibb plunged by 20% after it admitted that its lung cancer drug Opdivo had failed to meet several goals in clinical trials for new treatment areas. It will continue to market the drug as a standalone therapy and in combination with stablemate Yervoy, but growth prospects for Opdivo were scaled back from their previous highs. The setback delivered a huge boost to rival drug Keytruda, marketed by Merck & Co. The two drugs have been competing fiercely for leadership in several cancer treatment areas, with BMS hitherto considered the clear winner. For the first six months of 2016, Opdivo generated sales of $1.5bn, almost three times Keytruda's tally. This setback will level the playing field somewhat, with analysts predicting a surge for Keytruda at Opdivo's expense. These are both still giant drugs - analysts expect Opdivo's sales to peak at over $10bn by 2025 (down from previous estimates of over $13bn), while Keytruda estimates were lifted from $5bn to almost $8bn.
Adbrands Weekly Update 7th Jan 2016: Bristol-Myers Squibb effectively pulled out of the HIV drug development market, by agreeing to sell all its pipeline products in that segment to rival ViiV Healthcare, a unit of GlaxoSmithKline. It will continue to market its current portfolio of approved HIV drugs including Sustiva, Reyataz and Atripla. The price of the deal could be up to $2.9bn depending on the future performance of the new drugs.
Adbrands Weekly Update 31st Dec 2013: AstraZeneca is to pay up to $4.1bn to buy out partner Bristol Myers-Squibb from their diabetes joint venture which markets a range of products including Onglyza, Kombiglyze and Forxiga.
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