The global pharmaceutical market was worth $996bn in 2017, up almost 3% on the year before. The US accounted for 45% of that total, or $453bn. Europe contributed a further 21% (or $214bn), and the rest of the established world for 11% (or $112bn). The fastest growth continues to come from emerging markets, where sales rose by almost 8% in 2017 to $216bn. The top five markets by value are the US, Japan, China, Germany and France. Drug development has slowed dramatically as a result of rising costs. Despite a total R&D budget of $154bn in 2016, only 22 new drugs were approved by the US FDA in 2016, fewer than half the year before.

The World's Leading Pharma Companies in 2021 by healthcare revenues

Johnson & Johnson $93.8bn	Takeda $31.6bn
Pfizer $81.3bn	Eli Lilly & Co $28.3bn
Roche $68.7bn	Bayer $28.2bn
AbbVie $56.2bn	Gilead Sciences $27.3bn
Novartis $51.6bn	Amgen $26.0bn
Merck & Co $48.7bn	Boehringer Ingelheim $24.4bn
Bristol-Myers Squibb $46.4bn	Novo Nordisk $22.4bn
Glaxo SmithKline $46.0bn	BioNTech $22.4bn
Sanofi $44.7bn	Moderna $18.5bn
AstraZeneca $37.4bn	Viatris $17.8bn

Source: company reports

The World's Top 20 Prescription Drugs in 2021 by global sales

Comirnaty $36.8bn Pfizer, BioNTech	Opdivo $8.5bn BMS
Humira $20.7bn AbbVie	Xarelto $7.5bn Bayer/ J&J
Spikevax $17.75bn Moderna	REGEN-COV/Ronapreve $7.5bn Regeneron/Roche
Keytruda $17.2bn Merck	Trulicity $6.5bn Eli Lilly
Eliquis $16.7bn BMS / Pfizer	Darzalex $6.0bn Janssen / J&J
Revlimid $12.8bn BMS	Trikafta/Kaftrio $5.7bn Vertex
Imbruvica $9.8bn AbbVie / J&J	Gardasil 9 $5.7bn Merck
Stelara $9.1bn Janssen / J&J	Dupixent $5.6bn Sanofi / Regeneron
Eylea $8.9bn Bayer / Regeneron	Veklury $5.6bn Gilead Sciences
Biktarvy $8.6bn Gilead Sciences	Ibrance $5.4bn Pfizer

Source: Fierce Pharma, company reports

The World's Top Consumer Health Companies in 2017

Johnson & Johnson $13.6bn	Reckitt Benckiser $6.9bn
GlaxoSmithKline $10.5bn	Sanofi $4.8bn
Amway $8.6bn	Herbalife $4.4bn
Procter & Gamble $7.5bn	Pfizer $3.5bn
Bayer $7.0bn	Nature's Bounty $3.3bn

Source: Igea, company reports; includes skincare, personal care, oral care, nutritionals, vitamins & hygiene

The World's Top Animal Healthcare Companies in 2014

Zoetis (ex-Pfizer) 20% global share	Merial (Sanofi) 12%
Elanco/Novartis AH (Eli Lilly & Co) 15%	Bayer 7%
Merck & Co 14%	Boehringer Ingelheim 6%

Source: PwC

Top US OTC Products in 2013 by sales

Advil (Pfizer) $615m	Alcon (Novartis) $447m	Dr Scholl's (Merck*) $370m
Nature Made $596m	Claritin (Merck*) $430m	Aleve (Bayer) $364m
Mucinex (Reckitt) $578m	Depend (Kimberly-Clark) $393m	Prilosec OTC (P&G) $359m
Ensure (Abbott) $496m	Poise (Kimberly-Clark) $379m	5 Hour Energy $332m

* Bayer from 2014. Source: Main products including biggest variants; IRI 52 wks to Jan 2014 all channels, Drugstorenews

Other companies profiled in Adbrands

Teva	Astellas Pharma
Bausch Health (formerly Valeant)	Abbott Laboratories

Gone But Not (Completely) Forgotten

Warner-Lambert	Smithkline Beecham
Wyeth	Aventis
Schering-Plough	Pharmacia